Miniprotein quick-yak-crystal

Google DeepMind / quick-yak-crystal

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1111

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (118 AA)

ADPEEVKRAEAEFFRLAGEIGRAGAAGDEKRAREAAIRALEVFVKHGEDMIAAADAVTRRNLLDLALAVAEAVSGTTDEEIRKKAIELCELVAKAAAEAGDTELARRAADLLRHLKEL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.04pH

Molecular Weight

12.7kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

2.1×10⁻⁷M

k_on

2.5×10⁵M^-1s^-1

k_off

5.1×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN