Miniprotein noble-toad-clay

Google DeepMind / noble-toad-clay

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0827

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (119 AA)

SVVDKLLEAAKLVRQGKVDEAIELAVEAAAEIKDPEERELVVKAITLALSIVASLQHGSLESARYLTDQFIETLKKLPEPLKKALAEFAIALLEEEAPHLSPEQRAAARELIDRIKSSI

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.01pH

Molecular Weight

13.0kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

9.6×10⁻⁷M

k_on

1.5×10⁵M^-1s^-1

k_off

1.5×10⁻¹s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN