Miniprotein noble-mole-wave

Google DeepMind / noble-mole-wave

Type

Miniprotein

Binding

Human VEGF110

Weak

Expressed

Yes

Ref

PDW_0826

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (119 AA)

SVVDKLREAAELVRAGKVDEAIELAVEAAAEIKDPEERELVVKAITLALSIVASLQHGSLESARYLTDKFIETLKKLPKPLQEALADFAIALLENEAPRLTPEQQAAAAELIKRIKASI

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.99pH

Molecular Weight

12.9kDa

Download CIF

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Binding

Yes

Binding Strength

Weak, Medium

K_D

1.0×10⁻⁶M

k_on

4.5×10⁴M^-1s^-1

k_off

4.5×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN