Miniprotein jade-ox-opal | Proteinbase

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Design Methods
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Competitions

Created by

GD

Google DeepMind / jade-ox-opal

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1164

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (101 AA)

AVTATVTLDADTFKPGETVTATGTVWGSGFPAGSRAFVVVKAFDEDGSEIASGSGTGDVPGTVTATVTVPANASKVRAFAGYGVLGTGSGYVLASAEAAVV

Sequence (101 AA)

AVTATVTLDADTFKPGETVTATGTVWGSGFPAGSRAFVVVKAFDEDGSEIASGSGTGDVPGTVTATVTVPANASKVRAFAGYGVLGTGSGYVLASAEAAVV

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.36pH

Molecular Weight

9.8kDa

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Binding

Yes

Binding Strength

Strong

K_D

2.7×10⁻⁸M

k_on

7.0×10⁴M^-1s^-1

k_off

1.4×10⁻³s^-1

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN

Proteins
jade-ox-opal

Miniprotein jade-ox-opal | Proteinbase

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM