Miniprotein jade-orca-birch | Proteinbase

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Design Methods
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Miniprotein jade-orca-birch | Proteinbase

GD

Google DeepMind / jade-orca-birch

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0819

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (60 AA)

VSLEEIAEAHNYLYERSKTLPEGEEGDAKFVKMVELYIKLQEGEISLEEFKEEADKILAK

Sequence (60 AA)

VSLEEIAEAHNYLYERSKTLPEGEEGDAKFVKMVELYIKLQEGEISLEEFKEEADKILAK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.52pH

Molecular Weight

6.9kDa

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Binding

Yes

Binding Strength

Medium

K_D

1.0×10⁻⁷M

k_on

1.2×10⁶M^-1s^-1

k_off

1.2×10⁻¹s^-1

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN

Proteins
jade-orca-birch

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM