Miniprotein ivory-cobra-marble

Google DeepMind / ivory-cobra-marble

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1337

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (109 AA)

PRIRQMLHDAGELLERAIADEDAQEALALVMEALDVIHSLGDLSYKGGRLAQDAYDIFRQLLKSLGLTFKSGMTLEEIVNLFRQAKERATLAQSRALAAQLLDLVREME

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.03pH

Molecular Weight

12.2kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

1.9×10⁻⁷M

k_on

1.3×10⁵M^-1s^-1

k_off

2.6×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN