Miniprotein hollow-moth-vine

Google DeepMind / hollow-moth-vine

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1295

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (118 AA)

ADLEQVKKAEGEFFRLTGEIGRAGLAGDAARARAAAVRALEVLVENGRDMLAMADKNTRRALLDLGLATLDSLSGTTDAEIQKKGIEGAELVAKEAMEDGDEHLAAKARDLLDHLKSL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.95pH

Molecular Weight

12.5kDa

Download CIF

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Binding

Yes

Binding Strength

Medium, Strong

K_D

4.1×10⁻⁸M

k_on

5.3×10⁵M^-1s^-1

k_off

2.0×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN