Miniprotein hollow-bear-willow

Google DeepMind / hollow-bear-willow

Type

Miniprotein

Binding

PD-L1

Strong

Expressed

Yes

Ref

PDW_1544

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (113 AA)

EEDKLEQYKRVLDSLVERARAAKTDREKQNIFVMVVMIGLIRLHEEQDVEVQKEIAELVLEACERIIPLLSEESKEKALEIIKKIYEKIAKEATDEKKQMMSELLERIEKLVQ

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.03pH

Molecular Weight

13.3kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

3.6×10⁻¹⁰M

k_on

1.2×10⁵M^-1s^-1

k_off

4.3×10⁻⁵s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN