Miniprotein golden-ibis-clay

Google DeepMind / golden-ibis-clay

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0995

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (94 AA)

LRDRRAKLINGLHEMLGIVRESLRGQEEKYLELEGPFEEAVIALTKAGLTGSEAALREAEAAIRDFMELAIDILEEEGKTDAVGQLKEIYDKYF

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.67pH

Molecular Weight

10.6kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

2.2×10⁻⁹M

k_on

1.5×10⁶M^-1s^-1

k_off

3.0×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN