Miniprotein gentle-moth-leaf

Google DeepMind / gentle-moth-leaf

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0816

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (94 AA)

LLERRARLINALHEVLKVVLEALKGKEEELEKLEGPFADAVYALVEAGLTGSEAALERAEAAVRAFIEAARETLEKLGKEEAVKKLEEIEAKYF

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.94pH

Molecular Weight

10.4kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

5.7×10⁻¹⁰M

k_on

1.4×10⁵M^-1s^-1

k_off

6.6×10⁻⁵s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN