Miniprotein frozen-bee-ash

Google DeepMind / frozen-bee-ash

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1263

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (101 AA)

LCTATLTVDRKTAHPGDTVTASATGTGACTVSGAKVFVVILAFDASGNQVASASGSAGCGETATAELTVPSGASKVLCLAGVGYPEANTGYIDDWAEITVT

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.35pH

Molecular Weight

9.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

1.7×10⁻⁷M

k_on

9.1×10⁴M^-1s^-1

k_off

1.5×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN