Small Protein deep-quail-wave

Google DeepMind / deep-quail-wave

Type

Small Protein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1109

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (136 AA)

SIEELLAEARALLRSTDGAERRRAVDTLLKIAEKAEKASPEQIREAAELALEAAQREAEDPNGSLGNALEALKAALGLVPMLPREEALALLERMREILERLRERAKTIPDENARKSVLDEVDELLERIDHLEAALA

Computational Metrics

Experimental Metrics

Design Class

Small Protein

Isoelectric Point

4.76pH

Molecular Weight

15.1kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

3.2×10⁻⁷M

k_on

2.6×10⁵M^-1s^-1

k_off

7.2×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN