Miniprotein deep-crow-thorn

Google DeepMind / deep-crow-thorn

Type

Miniprotein

Binding

PD-L1

Strong

Expressed

Yes

Ref

PDW_1387

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (99 AA)

SSEELFEDLKRIVKSVFNTIKRAVEELDKERALELTEALLELLGGIIKNHIHSLSEEQKEELKELIKEEAEKLIKEVKDEEIKKLIKEKVDEILELLEK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.87pH

Molecular Weight

11.6kDa

Download CIF

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Binding

Yes

Binding Strength

Strong, Medium

K_D

8.6×10⁻⁸M

k_on

7.0×10⁴M^-1s^-1

k_off

5.7×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN