Miniprotein deep-crane-oak | Proteinbase

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Miniprotein deep-crane-oak | Proteinbase

GD

Google DeepMind / deep-crane-oak

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0818

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (60 AA)

VTLEEIAEAHNYLHEKSKTLPEGEEGDAKFVKMVELYIDLQNGKISLEEFKKKADEILAK

Sequence (60 AA)

VTLEEIAEAHNYLHEKSKTLPEGEEGDAKFVKMVELYIDLQNGKISLEEFKKKADEILAK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.92pH

Molecular Weight

6.9kDa

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Binding

Yes

Binding Strength

Medium

K_D

1.4×10⁻⁷M

k_on

1.3×10⁶M^-1s^-1

k_off

1.8×10⁻¹s^-1

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN

Proteins
deep-crane-oak

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM