Miniprotein deep-cobra-frost

Google DeepMind / deep-cobra-frost

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1607

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

SGLTKLKTFAEEALKLLQEILEAPRQEKPRLLEELVRFFNEKLAEIPKELLPAAGLLAVLTLTIASAVLDLPPERLPAVCENLITTAEHLSPKFDEEVAQLILDTLRQAHKLVQQYVARQ

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.23pH

Molecular Weight

13.5kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

8.7×10⁻⁸M

k_on

8.8×10³M^-1s^-1

k_off

7.6×10⁻⁴s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN