Miniprotein crimson-toad-lava

Google DeepMind / crimson-toad-lava

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1411

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

EEELEKEVRKLVNEAGLAIAAGDEERALELADRIVELARKAADLGHRDLARTAISALLLLAAKALVEGNVELAYKLAKLAVETALELGLEGLAKTIARTAAYLLERAGRKELAEELLKLA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.06pH

Molecular Weight

12.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

1.1×10⁻⁷M

k_on

4.1×10⁴M^-1s^-1

k_off

4.6×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN