Miniprotein crimson-bison-crystal

Google DeepMind / crimson-bison-crystal

Type

Miniprotein

Binding

PD-L1

Weak

Expressed

Yes

Ref

PDW_1585

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (118 AA)

TLEEIDQIKQEILEILEQIAEILNKLDPKKAKEVSRQLLQYLENQAEEATDLKVRESYIIARVILGAVLGGVLNGNPQAGLEVARQILDVVAQHAPELLPGILEALKEALDKLLQLVA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.63pH

Molecular Weight

13.0kDa

Download CIF

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Binding

Yes

Binding Strength

Weak, Medium

K_D

9.2×10⁻⁷M

k_on

5.7×10⁴M^-1s^-1

k_off

4.9×10⁻²s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN