Miniprotein calm-falcon-ruby

Google DeepMind / calm-falcon-ruby

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1557

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (92 AA)

SLESKLKDILNKIAEAKNRIEIIKLLQELKTLLQDADLELAKFAAVAAILIAGKLLHMPREIIEGYVIEIHKSKNKEELLKILDDFIDRLEK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

6.11pH

Molecular Weight

10.5kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

5.3×10⁻⁸M

k_on

8.2×10³M^-1s^-1

k_off

4.3×10⁻⁴s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

1.00 nM

3.16 nM

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (non-distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, non-distortionary keys

temperature0.5

sequenceDesignProteinMPNN