Miniprotein brisk-crow-clay

Google DeepMind / brisk-crow-clay

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1355

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

SAEEKVLANLENMKKKALNAKTEEEKLVYAKALVAVALSYAIRGDEALAERAAELAVEVINSLSKEQQKKVMDFAINMIKNVTDPEDREVAIELLVRMAERLPEEVRKEALKKIEELKKE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.30pH

Molecular Weight

13.6kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

2.6×10⁻⁷M

k_on

1.4×10⁴M^-1s^-1

k_off

3.6×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN (no watermark)

Parameters

backboneAlphaProteo

watermarknone

temperature0.1

sequenceDesignProteinMPNN