Miniprotein vast-vole-leaf

Google DeepMind / vast-vole-leaf

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1479

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (99 AA)

TSSELFEDIKFIIESVFNAILRSVKELDRERALRVSKALLDLLNGILENHISLLSERQKRLLKELIEKLANKLIKEIKDDELRELIKEKTDKIIELLEE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.36pH

Molecular Weight

11.6kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

2.3×10⁻⁷M

k_on

1.1×10⁴M^-1s^-1

k_off

2.4×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN