Miniprotein vast-cobra-vine

Google DeepMind / vast-cobra-vine

Type

Miniprotein

Binding

Human VEGF110

Weak

Expressed

Yes

Ref

PDW_0911

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (60 AA)

VTPEEIAEAHQYLYDESKRLPAGEEGDAIFVKMVNLYIQLQEGKITYEEYRREADKLLAR

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.72pH

Molecular Weight

7.0kDa

Download CIF

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Binding

Yes

Binding Strength

Weak, Medium

K_D

8.8×10⁻⁷M

k_on

3.0×10⁵M^-1s^-1

k_off

2.6×10⁻¹s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN