Miniprotein strong-cobra-opal

Google DeepMind / strong-cobra-opal

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0903

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (94 AA)

IEERRAALLNGLHEALKVIKEALKGKEKELDELEGPLAEALYALTKAGISRTEAALDEAEAAVRAFLDRAREVLEKQGQEEAVEKLRELEARYL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.93pH

Molecular Weight

10.5kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

5.7×10⁻¹⁰M

k_on

1.3×10⁶M^-1s^-1

k_off

7.4×10⁻⁴s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN