Miniprotein solid-eagle-stone

Google DeepMind / solid-eagle-stone

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1452

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (107 AA)

TSLEQALADLEVLLEQALAEKDREEVVSLLKFIALLTKHAAEQGNIDIAERCKALFERGLVAAAPILSEEDLERLKEVFEKLRDAAKTDYAKALLDRMIEVIDRLIE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.67pH

Molecular Weight

12.0kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

1.3×10⁻⁷M

k_on

8.2×10⁴M^-1s^-1

k_off

1.1×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN