Miniprotein small-gecko-granite

Google DeepMind / small-gecko-granite

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1208

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (87 AA)

PLSVKEVAAAIKKAKDAANRHGPVTLGDLIGLALGNDRLNKWFEERTGLDPEEALEWIQNGDIDRIDEAEARAKPVIEELEEALKEL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.60pH

Molecular Weight

9.6kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

1.1×10⁻⁸M

k_on

7.5×10⁵M^-1s^-1

k_off

7.2×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN