Miniprotein silver-cobra-jade

Google DeepMind / silver-cobra-jade

Type

Miniprotein

Binding

Human VEGF110

Strong

Expressed

Yes

Ref

PDW_0944

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (129 AA)

KAALEQATEATQKELTALIDEIVQQSRGFSEKDREALSDLITACTNAMNIVQRRLLGTEDEIPDSGDSRVDAFLAEMEAADLGRLPELLRRFRDDLIEDFELSERAEALANKLVARAEALMAALLATSA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.40pH

Molecular Weight

14.2kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Strong

K_D

1.3×10⁻⁸M

k_on

2.1×10⁶M^-1s^-1

k_off

2.9×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN