Peptide rapid-toad-opal

rooshanie ejaz / rapid-toad-opal

Type

Peptide

Ref

RBX1_l79_s776245_mpnn1

Collections

R[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (79 AA)

FDEVIHRMHQVFWRYKETVPWEEAAGRERRIMRWNEDGSMEFIIEKEPGFEVPPLTGIPATTVEETETRTVYTVRLPEE

Computational Metrics

Experimental Metrics

Design Class

Peptide

Isoelectric Point

4.83pH

Molecular Weight

9480.56Da

Download CIF

Loading structure viewer...

No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using EBindCraft

BindCraft (Pacesa et al., 2025) with default 4stage_multimer settings. Target: RBX1 RING domain (res 40-108) from PDB 4F52 chain B. Hotspots: A43-44,A46,A55,A86-87,A91,A95-96,A98 (E2/GLMN-binding surface). Binder lengths: 60-140 AA. Sequence redesign: SolubleMPNN. Filtering: default BindCraft filters (pLDDT, i_pTM, i_pAE, Rosetta dG, shape complementarity, clash count, binder RMSD). Executed on NVIDIA A100 80GB GPUs.