Miniprotein quick-mole-maple

Google DeepMind / quick-mole-maple

Type

Miniprotein

Binding

Human VEGF110

Medium

Expressed

Yes

Ref

PDW_0977

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (127 AA)

SVESVIELLRKTEQSVEAGDLESALEDLRQAIEAVMKQEDLSEEAVELIKRGIDALEAGDFDLADELLLEASQLAHKEGGSLTTHAVIAAALLLGVALRSKDPNLRRAVARDIKLLIDLLEEYHRRQ

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.61pH

Molecular Weight

14.0kDa

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Binding

Yes

Binding Strength

Medium

K_D

1.2×10⁻⁷M

k_on

6.8×10⁵M^-1s^-1

k_off

7.8×10⁻²s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN