Miniprotein hollow-ram-snow

Google DeepMind / hollow-ram-snow

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1494

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (118 AA)

SSAEVAALVDRIRGILEQIAEMLKQLPKAEAREVSRRLLEYLEKKADEAEDREVRAAFIVAKIILGAVLGGVLNGNPEAGLAVAEKILEVVATHMPELLPRVLEALEDALALLKELVA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.89pH

Molecular Weight

12.8kDa

Download CIF

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Binding

Yes

Binding Strength

Medium

K_D

3.6×10⁻⁷M

k_on

2.6×10⁴M^-1s^-1

k_off

8.2×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

1.00 nM

3.16 nM

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN