Protein hollow-heron-ruby

Khondamir Rustamov / hollow-heron-ruby

Type

Unknown

Ref

design_38_m_1_full_cycle_11

Collections

X[GEM x Adaptyv: RBX1 Binder Design Competition] FoldCraft on Boltz

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (174 AA)

SVDREALIRRGAETLSRRVAEAIKKLDFIKGEKAERVKRLAPGLAGELARALLTTSFESKTLEELEAGRAEAVANFVRRLLESLFGEIPDLEIKVEIDKDDRLRFTLSVKLLIEDATEDDINGALAALGATAITLAELGKGAAKALGVGAIKVELESDNVDLSKLKALAAELGK

Computational Metrics

Experimental Metrics

Structure prediction unavailable

It might take a few hours to appear.

No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using KRFoldCraft

We employed 3stage design protocol (100,100,20) from ColabDesign with our FoldCraft loss for AF2-Multimer hallucination. Only FoldCraft loss was used for design without other AF2 loss functions. ProteinMPNN model with temperature 0.1 generated 2 sequences per designs. The design algorithm was set in loop until we got at least 100 binder passing BindCraft filters.