Miniprotein hollow-hawk-sand

Google DeepMind / hollow-hawk-sand

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1212

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (87 AA)

PLSVKEVAAAIKKGKEANGRSGPVTLGDLIGLALGDEALNKWFKERTGLDPEEALEDIQKGNQAKIDQAEALAAPVLAALEAAIKEL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.78pH

Molecular Weight

9.1kDa

Download CIF

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Binding

Yes

Binding Strength

Medium, Strong

K_D

4.3×10⁻⁸M

k_on

8.0×10⁵M^-1s^-1

k_off

3.2×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN