Miniprotein green-seal-clay

Google DeepMind / green-seal-clay

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Strong

Expressed

Yes

Ref

PDW_1257

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (101 AA)

TVTATVSLDRETFRPGETVTATGTVWGDGFPDGARAFVTVKAYDKDGGEIDAGTGTGDVPGTVTATVTVPAEASKVQAFAGFGVLGTAEGRVLATAEADVV

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.24pH

Molecular Weight

10.1kDa

Download CIF

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Binding

Yes

Binding Strength

Strong

K_D

1.6×10⁻⁸M

k_on

2.6×10⁵M^-1s^-1

k_off

3.2×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN