Miniprotein deep-ram-marble

Google DeepMind / deep-ram-marble

Type

Miniprotein

Binding

PD-L1

Medium

Expressed

Yes

Ref

PDW_1476

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (98 AA)

TAEEDKIKKLMQEGNYDEALKLLEESKNLSRTDKRHLGLLLFMAAAQHKDSQLALKVIDLLARQQVVTEEAAKTIIAILEKLLPELVEQAREILERAL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.42pH

Molecular Weight

11.1kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium

K_D

2.1×10⁻⁷M

k_on

1.0×10⁵M^-1s^-1

k_off

2.2×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN