Miniprotein dark-fox-reed

Google DeepMind / dark-fox-reed

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Weak

Expressed

Yes

Ref

PDW_1214

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

LSADVDAAITTLSIGADLIAHGEESQEVAAALRALSDDQIKAALDAMGRKAEELEAGGKEIQARGTKVLMLLGAGAYRAVKAGKALGDVDPVQLLNAVFKEAGPIESVKEAREAAIKFTK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.03pH

Molecular Weight

12.4kDa

Download CIF

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Binding

Yes

Binding Strength

Weak

K_D

1.5×10⁻⁶M

k_on

3.8×10⁴M^-1s^-1

k_off

5.5×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN