Miniprotein dark-dove-flint

Google DeepMind / dark-dove-flint

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Medium

Expressed

Yes

Ref

PDW_1204

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (118 AA)

PNPKQVKAAAAEFSRLTGEIGRAGAAGDEERARAAAREALRVLYRHGRDMLEAADATTRRVLLDLGLAVIHALSGTTDEEIRALAIAAAELVAKYAREAGDEELAQKAEDLLAHLKSL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.65pH

Molecular Weight

12.6kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Medium, Strong

K_D

4.8×10⁻⁸M

k_on

1.7×10⁵M^-1s^-1

k_off

7.7×10⁻³s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN