Miniprotein dark-cobra-granite

Google DeepMind / dark-cobra-granite

Type

Miniprotein

Binding

PD-L1

Weak

Expressed

Yes

Ref

PDW_1471

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (98 AA)

TAEEDKIKKLMQEGNYDEALEVLEKATGLTKFDKRVLGIALFLAACQRQDAALALKVIKLMADKNIITEEAAKMILAVLEKLLPELVEQAREILEKAL

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.06pH

Molecular Weight

10.9kDa

Download CIF

Loading structure viewer...

Binding

Yes

Binding Strength

Weak

K_D

1.3×10⁻⁶M

k_on

2.3×10⁴M^-1s^-1

k_off

3.0×10⁻²s^-1

Download raw data

Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

Loading kinetic curves...

Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN