Miniprotein crimson-ox-flint

Google DeepMind / crimson-ox-flint

Type

Miniprotein

Binding

SARS-CoV-2 RBD

Weak

Expressed

Yes

Ref

PDW_1216

Collections

DSynthIDBio: watermarked protein binders (Google DeepMind)

Sequence (120 AA)

LSADVDAAITTLSIGADLIAHGEESQEVAAALRALSDDQIEAAIEAMGRKAQEYEAAGKEKAARGTMNLILLGAGAYKAVKAGKRLASVDPVDALNEVFKTAGAVESVDEARAAALAYIK

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.75pH

Molecular Weight

12.3kDa

Download CIF

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Binding

Yes

Binding Strength

Weak

K_D

1.3×10⁻⁶M

k_on

2.3×10⁴M^-1s^-1

k_off

3.0×10⁻²s^-1

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Kinetic Curves (SPR)

Concentration

10.0 nM

31.6 nM

100 nM

316 nM

1000 nM

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Design Method

This protein was designed using GDAlphaProteo backbone + ProteinMPNN with SynthIDBio (distortionary)

Parameters

backboneAlphaProteo

watermarkSynthIDBio-sequence, distortionary keys

temperature0.1

sequenceDesignProteinMPNN