Miniprotein wild-jaguar-willow

Anurup Krishna / wild-jaguar-willow

Type

Miniprotein

Ref

RBX1v10_l70_s265401_mpnn4

Collections

A[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (70 AA)

SARERALEELRRRLEEENRRADVEVMQEIVPRLYSGELSHEEAHAIHLARSRELREREREELERLERELE

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

5.19pH

Molecular Weight

8590.41Da

Download CIF

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No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using EBindCraft

A local installation of FreeBindCraft with PyRosetta was used for this campaign(https://github.com/cytokineking/FreeBindCraft?ref=blog.escalante.bio), using the following settings:

-Miniprotein -Target chain: A -Hotspot Residues: A35,A36,A37,A64 -Min/Max Length: 65/150 aa -Number of Final Designs: 100 -Filter Settings: default_filters -Advanced Settings: default_4stage_multimer