Miniprotein vast-cobra-birch

Anurup Krishna / vast-cobra-birch

Type

Miniprotein

Ref

RBX1v10_l74_s804221_mpnn4

Collections

A[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (74 AA)

SDTRISLEVMREMDRRYRERAEEVYASYGPEDFEMNEHGRLAPSQKMREELHKIFMEVWEEGTRRDDEVLAARP

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.92pH

Molecular Weight

8961.88Da

Download CIF

Loading structure viewer...

No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using EBindCraft

A local installation of FreeBindCraft with PyRosetta was used for this campaign(https://github.com/cytokineking/FreeBindCraft?ref=blog.escalante.bio), using the following settings:

-Miniprotein -Target chain: A -Hotspot Residues: A35,A36,A37,A64 -Min/Max Length: 65/150 aa -Number of Final Designs: 100 -Filter Settings: default_filters -Advanced Settings: default_4stage_multimer