Generation: 29 sequences, length 25 aa, targeting RBX1 hotspot motif (residues 18–36). Scoring: PeptiVerse API — binding affinity vs RBX1 (pKd), solubility, hemolysis, half-life at pH 7.4. Selection: all 29 sequences included. 14 tight-binding (pKd ≥ 9.0), 15 medium-binding (pKd 7–9). Best binder: pKd = 9.761.