Protein bright-bear-cloud

Anurup Krishna / bright-bear-cloud

Type

Other

Ref

RBX1v10_l114_s718102_mpnn7

Collections

A[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (114 AA)

SEMEKKIEFYLKKFEEELNSEELQSEINRQLEFFKHELARTSDPEDHEIFKKIVTNTLMHLLREAAEKVFKEYEPEDMSEEEKEKIKKALEEKVEEEMKKYEKELEEMLEEVKS

Computational Metrics

Experimental Metrics

Design Class

Other

Isoelectric Point

4.72pH

Molecular Weight

1.39e+4Da

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No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using EBindCraft

A local installation of FreeBindCraft with PyRosetta was used for this campaign(https://github.com/cytokineking/FreeBindCraft?ref=blog.escalante.bio), using the following settings:

-Miniprotein -Target chain: A -Hotspot Residues: A35,A36,A37,A64 -Min/Max Length: 65/150 aa -Number of Final Designs: 100 -Filter Settings: default_filters -Advanced Settings: default_4stage_multimer