Used Boltz-2 to generate starting docks, followed by EvolveX (FoldX driven physics based sequence design algorithm; https://www.biorxiv.org/content/10.1101/2024.04.22.589762v2) to adapt initial sequence to new epitope. Unfortunately we could only select sequences based on how they scored when running Boltz-2 without MSA and with only 1 diffusion step.