BindCraft filtered by highest min ipSAE from boltz-2 scoring. Top 2 sequences selected with highest min_ipSAE.

target_hotspot:None predict_initial_guess: true, inter_contact_number=4. This gave me the original sequence. Made several single insertions (of G or A) at low importance positions based on the structure. Used our esm based: sequence (input) -> ipsae score (>0.8 classifier) model to classify them. This sequence had the highest confidence

https://github.com/gitter-lab/adaptyvbio-nipah/tree/main/bindcraft