The ability to design target and epitope specific binders has revolutionised the field of protein design. Here we combine various state-of-the-art approaches, such as RFdiffusion, BindCraft, AF3 and Boltz2 to iteratively design de-novo protein binders. In addition to convential scoring metrics such as ipTM and ipSAE we also include physics-based scoring methods to downselect and identify promising candidates for experimental validations.