A mix of structural knowledge and Gen AI based design protocol was used to generate the binders. First the Nipah Virus Glycoprotein G structural complex (PDB - 2VSM) was used to identify the interface residues contributing to its binding with EPHRIN-B2 using Protein Interactions calculator (https://caps.ncbs.res.in/pic) . Then BoltzGen was used to generate 10000 protein binders to block these interface residues using the protein anything protocol and the top 10 ranked designs from this protocol are used for final submission.