We used an custom modified version of PXDesign featuring improvements tailored for optimized antibody design. This modified framework was utilized to engineer both scFvs and nanobodies for the RBX1 target of this competition, with a primary focus on the precision design of CDR loops targeting specific protein residues, with a version of ProteinMPNN fine-tuned on structural antibody data. High-confidence models—prioritized by ipTM, ipSAE, and pLDDT metrics—were selected to determine if our modifications successfully improved design accuracy and binding potential.
id: quiet-fox-pearl

RBX1
None
80.89
True
25.8 kDa
249
id: dark-dove-ash

RBX1
None
76.44
True
26.1 kDa
249
id: deep-raven-plume

RBX1
None
80.98
True
26.0 kDa
249
id: swift-toad-iron

RBX1
None
82.32
True
25.9 kDa
249
id: quiet-bear-wave

RBX1
None
78.41
True
26.0 kDa
249
id: solid-fox-wave

RBX1
None
89.13
True
12.8 kDa
119
id: silver-yak-vine

RBX1
None
78.00
False
25.9 kDa
249
id: mellow-moth-leaf
No preview available
--
--
--
--
--
249
id: deep-gecko-birch
No preview available
--
--
--
--
--
249
id: silent-orca-vine
No preview available
--
--
--
--
--
249
id: noble-dove-crystal
No preview available
--
--
--
--
--
119
id: deep-yak-vine
No preview available
--
--
--
--
--
119
id: deep-eagle-sand
No preview available
--
--
--
--
--
119
id: dark-ant-oak
No preview available
--
--
--
--
--
119
id: bright-deer-clay
No preview available
--
--
--
--
--
119
id: frozen-bee-wave
No preview available
--
--
--
--
--
119
id: silver-heron-stone
No preview available
--
--
--
--
--
119
id: scarlet-otter-cedar
No preview available
--
--
--
--
--
119