Submitted toGEM x Adaptyv: RBX1 Binder Design Competition
Description
link to the pdf: https://drive.google.com/file/d/1JwVXCSDrn_0hlYxvtDdDcA6iutR35SFJ/view?usp=sharing
briefly: In this design challenge, we used a non-conventional targeting strategy that differs from traditional approaches aimed at designing stable monomers. We focus on generating designs that bind in a swapped conformation. This approach is based on the observation that a homolog of RBX1 forms a swapped dimer in the solved structure (PDB 4R2Y).