Human TrkA / NTRK1 (33-417) Protein

NTRK1 (TrkA) is the high-affinity NGF receptor and a key regulator of neuronal proliferation, differentiation and survival in the central and peripheral nervous systems. NGF binding triggers homodimerization, autophosphorylation and recruitment of effectors such as SHC1, FRS2, SH2B1/2 and PLCG1, activating overlapping survival and differentiation pathways. NTF3 can also activate the receptor but supports only axonal extension. Unliganded NTRK1 can promote cell death, making neurons dependent on trophic factor supply.