Protein strong-panther-plume

Brandon Cantrell / strong-panther-plume

Type

Unknown

Ref

rbx1_gen_0021|helix_v1_R6F,R8W,H9D,T18D|iPTM=0.842|pLDDT=0.802|composite=0.6751

Collections

B[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (18 AA)

HELSKFAWDENARMAAKD

Computational Metrics

Experimental Metrics

Boltz2 Complex Iplddt

0.72%

Boltz2 Complex Pde

0.56

Boltz2 Complex Plddt

0.68%

Boltz2 Ipsae

0.42

Boltz2 Iptm

0.83

Boltz2 Lis

0.51

Boltz2 Min Ipsae

0.42

Boltz2 Pdockq

0.02

Boltz2 Pdockq2

0.01

Boltz2 Plddt

0.71%

Boltz2 Ptm

0.84

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No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using BCSAE-Steered ESM2 + Topological Pre-Filtering + Boltz-2

Base model: facebook/esm2_t33_650M_UR50D (650M params, MPS-accelerated) SAE: InterPLM esm2-650m layer 18 (HuggingFace: Elana/InterPLM-esm2-650m) Steering feature: f5922 (helix), clamp=10.0 Topo filter: PH-entropy <= 1.1841 (linear), computed via ripser on Vietoris-Rips filtration Variants per parent: 5 (4 mutations each, temperature=1.0) Boltz-2 for structure prediction Target: RBX-1 RING domain residues 40-108, PDB 1LDK