Protein soft-crane-maple

Brandon Cantrell / soft-crane-maple

Type

Unknown

Ref

rbx1_gen_0008|helix_v1_M7W,E9K,A10K,E12I|iPTM=0.832|pLDDT=0.763|composite=0.6351

Collections

B[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (12 AA)

RAASEMWEKKNI

Computational Metrics

Experimental Metrics

Structure prediction unavailable

It might take a few hours to appear.

No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using BCSAE-Steered ESM2 + Topological Pre-Filtering + Boltz-2

Base model: facebook/esm2_t33_650M_UR50D (650M params, MPS-accelerated) SAE: InterPLM esm2-650m layer 18 (HuggingFace: Elana/InterPLM-esm2-650m) Steering feature: f5922 (helix), clamp=10.0 Topo filter: PH-entropy <= 1.1841 (linear), computed via ripser on Vietoris-Rips filtration Variants per parent: 5 (4 mutations each, temperature=1.0) Boltz-2 for structure prediction Target: RBX-1 RING domain residues 40-108, PDB 1LDK