Miniprotein rough-cobra-clay

Void Labs / rough-cobra-clay

Type

Miniprotein

Ref

r2_s2

Collections

V[GEM x Adaptyv: RBX1 Binder Design Competition] Submission 1

AGEM x Adaptyv RBX1 Binder Competition: Main Submissions

Sequence (65 AA)

SEFEEANKELKEAVTSDLPEEEREKVSKEAAEEVTEASYELIKEAGLPEPKSNEELSEAVREALA

Computational Metrics

Experimental Metrics

Design Class

Miniprotein

Isoelectric Point

4.23pH

Molecular Weight

7236.74Da

Download CIF

Loading structure viewer...

No experimental data

This protein hasn't been validated in the lab yet.

Design Method

This protein was designed using VLMosaic (Weights-optimized) — Protenix2025 + Boltz2

Protenix2025 hallucination, simplex-APGM optimizer. Phase 1: 120 steps (stepsize 0.15sqrt(65), momentum 0.3). Phase 2: 20 sharpening steps (stepsize 0.5sqrt(65), scale 1.3). 4 recycling steps, 20 feature sampling steps. Loss weights: 1.5x BinderTargetContact, 1.0x WithinBinderContact, 0.1x TargetBinderPAE, 0.1x BinderTargetPAE, 0.1x IPTMLoss, 0.4x WithinBinderPAE, 0.025x pTMEnergy, 0.1x PLDDTLoss, 8.0x MPNN SequenceRecovery (temp=0.01), 0.1x RadiusOfGyration, 0.5x BinderTargetIPSAE, 0.5x TargetBinderIPSAE, 1.5x IPSAE_min, 5.0x NoCysteine. Boltz2 validation: best-of-5, 8 recycling steps. Filters: ipTM >= 0.90, min_ipSAE >= 0.70, pLDDT >= 0.90, cysteine = 0. Compute: Modal A100-80GB.